We recommend suppressing the original phrase regarding area 3

We surmise that results obtained from the experiments described in this section cannot serve to understand the role of I_NaL in arrhythmogenesis.

step one. Van Driessche W, Lindemann B: Amount reliance out of currents as a consequence of unmarried sodium-choosy skin pores within the frog epidermis. Nature. 1979; 282 (5738): 519-520 PubMed Conceptual | Journalist Complete Text

It indicates the solid findings submit through this manuscript are perhaps not warranted and that i dont approve the newest manuscript contained in this form

The latest article writers keeps clarified a number of the inquiries I raised inside the my personal earlier in the day review. Regrettably, every significant issues haven’t been addressed through this upgrade. Whenever i stated in my previous opinion, I consider they unrealistic that every people items can be set just from the several extra sentences. As an alternative there are particular basic concerns toward experimental construction and you will, most critically, into analysis.

This means this new solid findings put forward from this manuscript try not justified and that i never agree the manuscript inside mode

The article writers provides made clear a number of the inquiries I raised inside the my early in the day opinion. Regrettably, all major dilemmas haven’t been treated by this improve. Once i manufactured in my earlier in the day opinion, I deem they unrealistic that every people products will likely be fixed simply by a number of added paragraphs. Rather you may still find certain important issues toward experimental structure and you may, very significantly, towards research.

• The number one concern is when I observed the newest malfunction out-of the methods in the earlier version it had been you can easily so you can decode, which have nearly prime precision, any haphazard stimulus brands I chosen. Get a hold of to possess examples of so it reanalysis. No matter whether we pretend your actual stimulus featured in the an after date otherwise is actually continuously switching anywhere between laws and silence, brand new decryption is often near to primary. This is certainly a sign that decoding has nothing to accomplish with the coursework service genuine stimuli heard of the Transmitter it is opportunistically exploiting other features about research. The brand new manage analysis the new experts did, reversing the fresh stimuli brands, you should never address this problem since it is afflicted with exactly the same state. Essentially, just what classifier are allegedly using it’s time that has enacted as tape become.
• The main cause of it is presumably that people put non-separate investigation to possess education and you can evaluation. Of course, if I’m sure correctly (look for part 3), arbitrary sampling one half of data examples off a keen EEG trace aren’t independent study. Continual the analysis 5 times – new handle studies the writers performed – is not a sufficient means to fix target this concern. Randomly seeking examples regarding a time series which has had sluggish changes (like the sluggish trend activity you to allegedly dominates this type of recordings significantly less than these circumstances) often invariably have solid temporal correlations. Look for TemporalCorrelations.jpg set for 2D occurrence histograms and you can a correlation matrix exhibiting which.
• Due to the fact changed measures part brings greater detail now, it is still unclear about just what investigation were utilized. Conventional class research declaration exactly what research keeps (common columns from the study matrix) and you can what findings (common rows) were utilized. Things could well be a component however, usually this can be this new other EEG channels otherwise fMRI voxels etcetera. Observations usually are go out points. Here I guess the fresh authors switched new brutal products for the a good various other area having fun with dominating role investigation. It is not mentioned in the event your dimensionality is smaller with the eigenvalues. Anyway, I suppose the knowledge trials (built-up at the 128 Hz) was indeed upcoming utilized because the findings together with EEG streams transformed of the PCA were used once the keeps. The stimuli brands was assigned as the On the otherwise Regarding for each and every sample. A couple of fifty% of samples (and you can names) ended up being chose randomly having education, therefore the other people was utilized to possess testing. So is this correct?